Dietary Salvia hispanica L. Seed Counteracted Kidney Failure in Experimental Metabolic Syndrome

Metabolic Syndrome (MS) has become a major health hazard in the current world by triggering cardiovascular and renal pathologies. Chia seed is rich source of bioactive food components (n-3 fatty acids, antioxidants fiber, among others) with several benefits on health. Therefore, we hypothesized that intake chia could counteract kidney failure MS protecting against lipid accretion, oxidative stress fibrosis this tissue. An experimental model was induced feeding male Wistar rats for 3 months sucrose-rich diet (SRD) containing corn oil as fat. During next months, half animals continued SRD. The other received SRD which replaced Salvia hispanica L. seeds (chia) (SRD+C). control group reference (RD). In MS, dietary administration significantly decreased albumin glucose urine levels (p<0.05). reverted (SiriusRed-collagen staining), morphological anomalies altered markers (PEPCK FBPase) metabolism These effects were accompanied decrease accumulation triglycerides biomarkers (ROS peroxides) mechanisms included down-regulation key enzymes acid biosynthesis (ACC, FAS G6PDH) up-regulation antioxidant defenses (GSH, GR GPx activities). Dietary counteracted an indicating it be exceptional clinical management disorder.